1. Shirley Yeung, Catherine Salvato
INHIBIN AND OREXIN!
Shirley Yeung, Catherine Salvato

2. INHIBIN: Alpha and Beta
glycoprotein
gonads
sertoli cells (male)
granulosa (female - B)
placenta
target: pituitary gland

3. Source of Control production caused by: FSH
FSH (follicle stimulating hormone)
feedback hormone
production ceased by: activin
counteraction

4. Role in the Body ALPHA BETA suppresses FSH / FSHR progesterone
regulates hypothalamic-pituitary-gonadal axis (childhood + puberty - females)

5. Hypo and Hyper-secretion
both hyposecretion and hypersecretion are effects of FSH hypo/hyper-secretion
affects growth - puberty
Analogy
INhibin INHIBITS INner child

6. Orexin! Produced and received in hypothalamus above pituitary gland
Peptide hormone (amino acid)
Controlled by leptin, glucose
leptin: suppresses hunger
glucose: instant energy

7. Maintenance of Homeostasis
Wakefulness
keeps you alert
maintains long, consolidated walking period
Appetite
promotes desire for food
Sleep deprivation = more hunger
Some correlation with mood
high = happiness
low = sadness

8. Analogy Orexin is your inner alarm clock!
The “O” is shaped like a clock that keeps you awake for the day :D
(rexin)

9. Consequences HYPER-secretion: insomnia
difficulty sleeping, even when tired
can be caused by stress
HYPO-secretion: narcolepsy
loss of control over sleep
excessive tiredness, sudden bouts of sleep

10. Bibliography: Inhibin
"Activin and Inhibin Effects." Activin and Inhibin Effects. N.p., n.d. Web. 11 Feb <
Chada, M., R. Prusa, J. Bronsky, M. Pechova, K. Kotaska, and L. Lisa. "PubMed." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 11 Feb <
De Jong, FH. "PubMed." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 11 Feb <
Ibanez, L., C. Valls, M. Cols, A. Ferrer, M.V. Marcos, and F. De Zegher. "PubMed." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 11 Feb <
Lu, C., W. Yang, T. Liu, J. Yang, P. Tan, L. Li, X. Hu, C. Fan, Z. Hu, and Y. Liu. "PubMed." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 11 Feb <

11. Bibliography: Orexin Works Cited:
Blouin, Ashley. "Abstract." National Center for Biotechnology Information. U.S. National Library of Medicine, 3 May Web. 11 Feb <
"Genes and mapped phenotypes." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 11 Feb <
"Insomnia (Chronic and Acute Insomnia) Causes and Symptoms." WebMD. WebMD, n.d. Web. 10 Feb <
"Narcolepsy Fact Sheet." : National Institute of Neurological Disorders and Stroke (NINDS). N.p., n.d. Web. 9 Feb <
"Orexin receptor antagonists: A new class of sleeping pill." National Sleep Foundation. N.p., n.d. Web. 11 Feb <
"Result Filters." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 11 Feb <
"Result Filters." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 11 Feb <
Tsujino, Natsuko , and Takeshi Sakurai. "Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System." Pharmological Reviews. American Society for Pharmacology and Experimental Therapeutics, n.d. Web. 11 Feb <