1. Addressing Treatment Challenges in Cystic Fibrosis

3. Program Goals

4. Pseudomonas aeruginosa

5. Eradication of Mucoid Pseudomonas Infection EPIC Clinical Trial*

6. EPIC Results

7. Management of Exacerbations

8. Cystic Fibrosis Guidelines

9. Cystic Fibrosis Guidelines

10. Why Don’t Physicians Follow Clinical Practice Guidelines?

11. Personalized Medicine Targeting the CFTR

12. Strategies for Modifying the Underlying Defect in CF

13. Strategies for Modifying the Underlying Defect in CF (cont)

14. Ivacaftor in Patients With CF and the G551D Mutation

16. F508 (F508del)

17. Corrector Therapy Phase 2 Results of Lumacaftor + Ivacaftor

18. Looking to the Future

19. Will Improving CFTR Function Affect Chronic Pseudomonas Infection?

20. Practical Advice to Address the Challenges of Complex Medical Regimens

21. Abbreviations

22. References

23. References (cont)

24. References (cont)

25. References (cont)