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Identification of IL18RAP/IL18R1 and IL12B as Leprosy Risk Genes Demonstrates Shared Pathogenesis between Inflammation and Infectious Diseases  Hong Liu,

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Presentation on theme: "Identification of IL18RAP/IL18R1 and IL12B as Leprosy Risk Genes Demonstrates Shared Pathogenesis between Inflammation and Infectious Diseases  Hong Liu,"— Presentation transcript:

1 Identification of IL18RAP/IL18R1 and IL12B as Leprosy Risk Genes Demonstrates Shared Pathogenesis between Inflammation and Infectious Diseases  Hong Liu, Astrid Irwanto, Hongqing Tian, Xi'an Fu, Yongxiang Yu, Gongqi Yu, Huiqi Low, Tongsheng Chu, Yi Li, Benqing Shi, Mingfei Chen, Yonghu Sun, Chunying Yuan, Nan Lu, Jiabao You, Fangfang Bao, Jinghui Li, Jian Liu, Huaxu Liu, Dianchang Liu, Xiulu Yu, Lin Zhang, Qing Yang, Na Wang, Guiye Niu, Shanshan Ma, Yan Zhou, Chuan Wang, Shumin Chen, Xuejun Zhang, Jianjun Liu, Furen Zhang  The American Journal of Human Genetics  Volume 91, Issue 5, Pages (November 2012) DOI: /j.ajhg Copyright © 2012 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Regional Association Plots of rs2058660 and rs6871626
The p values of SNPs (shown as −log10p) (y axis) are plotted against their map positions (x axis). The color of each SNP spot reflects its r2 with the confirmed SNP within each locus. The confirmed SNP, the top SNP, and previously reported SNPs of each locus are all in pink and are labeled with arrows. Estimated recombination rates (based on the combined CHB [Han Chinese in Beijing, China] and JPT [Japanese in Tokyo, Japan] samples from the 1000 Genomes Project) are plotted in light blue. Gene annotations were adapted from the UCSC Genome Browser (see Web Resources). (A) rs on 2q12.1. (B) rs on 5q33.3. The American Journal of Human Genetics  , DOI: ( /j.ajhg ) Copyright © 2012 The American Society of Human Genetics Terms and Conditions


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