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Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges  Luis M. Seijo, MD, PhD, Nir Peled, MD, PhD, Daniel Ajona, PhD, Mattia Boeri,

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Presentation on theme: "Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges  Luis M. Seijo, MD, PhD, Nir Peled, MD, PhD, Daniel Ajona, PhD, Mattia Boeri,"— Presentation transcript:

1 Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges 
Luis M. Seijo, MD, PhD, Nir Peled, MD, PhD, Daniel Ajona, PhD, Mattia Boeri, PhD, John K. Field, PhD, Gabriella Sozzi, PhD, Ruben Pio, PhD, Javier J. Zulueta, MD, PhD, Avrum Spira, MD, MSc, Pierre P. Massion, MD, Peter J. Mazzone, MD, MPH, Luis M. Montuenga, PhD  Journal of Thoracic Oncology  Volume 14, Issue 3, Pages (March 2019) DOI: /j.jtho Copyright © 2018 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Criteria for clinical use of biomarkers.
Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2018 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Currently explored biomarker candidates. miRNA, microRNA.
Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2018 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 Candidate biomarkers for lung cancer early detection and phase of development. AAb, autoantibody; CA-125, cancer antigen 125; CAGE, cancer-associated antigen gene; CEA, carcinoembryonic antigen; COPD, chronic obstructive pulmonary disease; CT, computed tomography; CYFRA, cytokeratin fragment; DIPN, diagnosis of indeterminate pulmonary nodules; FISH, fluorescence in situ hybridization; HGF, hepatocyte growth factor; HUD Hu antigen D, embryonic lLethal, abnormal vision, drosophila-like protein 4; LG3BP, galectin-3 recombinant protein; MAGE, melanoma-associated antigen; MIRNA, microRNA; MPO, myeloperoxidase; NBT, nanoparticle biometric tagging; NGS, next-generation sequencing; NSE, neuron-specific enolase; NY-ESO-1, New York esophageal squamous cell carcinoma 1; OPN, osteopontin; PRL, prolactin; PROGRP, progastrin-releasing peptide; PTGER4, prostaglandin E receptor 4; RASSF1A, an isoform of Ras association domain family member 1; RIMS, risk management screening context; SHOX2, short stature homeobox 2; SNP, single-nucleotide polymorphism; SOX2, SRY-box 2; TEC-Seq, targeted error correction sequencing; TIMP1, TIMP metallopeptidase inhibitor 1; VOC, volatile organic compound.116–131 Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2018 International Association for the Study of Lung Cancer Terms and Conditions

5 Figure 4 Design of a trial to test the clinical utility of one or several candidate biomarkers. CT, computed tomography; LDCT, low-dose computed tomography; SOC, standard of care; USPSTF, U.S. Preventive Services Task Force; PRO, patient-reported outcomes. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2018 International Association for the Study of Lung Cancer Terms and Conditions

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