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Volume 138, Issue 4, Pages (April 2010)

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1 Volume 138, Issue 4, Pages 1502-1513 (April 2010)
Genetic Risk Factors for Post-Infectious Irritable Bowel Syndrome Following a Waterborne Outbreak of Gastroenteritis  Alexandra–Chloé Villani, Mathieu Lemire, Marroon Thabane, Alexandre Belisle, Geneviève Geneau, Amit X. Garg, William F. Clark, Paul Moayyedi, Stephen M. Collins, Denis Franchimont, John K. Marshall  Gastroenterology  Volume 138, Issue 4, Pages (April 2010) DOI: /j.gastro Copyright © 2010 AGA Institute Terms and Conditions

2 Figure 1 Sampling flowchart of the Walkerton Health Study post-infectious irritable bowel syndrome (PI-IBS) cohort. The flowchart describes the participants' distribution of the Walkerton Health Study cohort (WHS) and of the eligible PI-IBS cohort that were included or not in the genetic association study. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

3 Figure 2 Compilation of association results for the Toll-like receptor 9 (TLR9) region. In the upper panel are the single nucleotide polymorphisms (SNPs) with their positions in the genes and the linkage disequilibrium (LD) structure between them. The upper left portion is D′ and the lower right portion is r2. In the lower panel are the results from association analysis of combined self-reported and confirmed (A) and of solely confirmed (B) eligible white Caucasian post-infectious irritable bowel syndrome (PI-IBS) cases and controls affected with gastroenteritis. P values for individual alleles are reported in a logarithmic scale on the Y-axis, with symbols representing the associated allele (▴ = A, ● = C, ▾ = T, ♦ = G). The color spectrum is used to represent the strength of LD and the frequency of the associated alleles. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

4 Figure 3 Compilation of association results for the IL6 region. Refer to Figure 2 legend for more details. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

5 Figure 4 Compilation of association results for the CDH1 region. Refer to Figure 2 legend for more details. Note that rs is a 1 base pair deletion whose deleted base is symbolized by ×. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions


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