1. Volume 14, Issue 5, Pages 485-496 (May 2015)
Association between brain imaging signs, early and late outcomes, and response to intravenous alteplase after acute ischaemic stroke in the third International Stroke Trial (IST-3): secondary analysis of a randomised controlled trial 
The Lancet Neurology 
Volume 14, Issue 5, Pages (May 2015)
DOI: /S (15)
Copyright © 2015 The IST-3 collaborative group. Open access article distributed under the terms of CC BY Terms and Conditions

2. Figure 1
Trial profile
The Lancet Neurology  , DOI: ( /S (15) )
Copyright © 2015 The IST-3 collaborative group. Open access article distributed under the terms of CC BY Terms and Conditions

3. Figure 2
Forest plot showing the adjusted effect of treatment and baseline imaging signs on Oxford Handicap Scale score 0–2 at 6 months
Data are adjusted for age, National Institutes of Health Stroke Scale score, and time to randomisation.
The Lancet Neurology  , DOI: ( /S (15) )
Copyright © 2015 The IST-3 collaborative group. Open access article distributed under the terms of CC BY Terms and Conditions

4. Figure 3
Forest plot showing the adjusted effect of treatment and baseline imaging signs on symptomatic intracranial haemorrhage within 7 days
Data are adjusted for age, National Institutes of Health Stroke Scale score, and time to randomisation.
The Lancet Neurology  , DOI: ( /S (15) )
Copyright © 2015 The IST-3 collaborative group. Open access article distributed under the terms of CC BY Terms and Conditions

5. Figure 4
Forest plot showing the interaction between response to alteplase and early infarct size in previous trials
ASPECTS=Alberta Stroke Programme Early CT Signs. ECASS II=European Co-operative Acute Stroke Study-II. IST-3=third International Stroke Trial. NINDS=National Institute of Neurological Disorders and Stroke. PROACT 2=Prolyse in Acute Cerebral Thromboembolism 2.
The Lancet Neurology  , DOI: ( /S (15) )
Copyright © 2015 The IST-3 collaborative group. Open access article distributed under the terms of CC BY Terms and Conditions