1. SCUF Slow Continuous Ultrafiltration
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2. Produced in partnership with The Royal London Hospital
Blood is circulated through a semi permeable haemofilter via an extracorporeal circuit.
Plasma water is pulled from the patients blood and into the waste/filtration bag by ultrafiltration.
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Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

3. Ultrafiltration The movement of fluid across a semi-permeable
membrane with a hydrostatic pressure.
A pressure gradient is created in the filter by the
blood pump, producing a positive pressure within the individual fibres.
The filtrate pump controls and regulates the convective flow of plasma water.
Produced in partnership with The Royal London Hospital
Copyright ©2015 NIKKISO Co., LTD. All rights reserved.
Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

4. Produced in partnership with The Royal London Hospital
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5. Primary Indications Fluid overload
Severe oedema Congestive heart failure Fluid volume management
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6. CVVHDF Continuous Veno-Venous Haemodiafiltration
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7. Blood is circulated through a highly permeable
haemofilter via an extracorporeal circuit.
Plasma water, water soluble small, middle, and large molecules are removed from the patients blood by ultrafiltration and convection. Also, small solutes
diffuse from the patients blood into a dialysate
solution.
Some fluid is replaced into the patients blood to
achieve the desired fluid balance.
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Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

8. Diffusion and Convection
The movement of solutes across a semi-permeable
membrane through a concentration gradient.
The movement of fluid across a semi-permeable
membrane creating solute drag.
As fluid is pulled across the membrane solutes
dissolved in the fluid are taken with it.
Small, middle, and large sized water soluble molecules are removed.
Produced in partnership with The Royal London Hospital
Copyright ©2015 NIKKISO Co., LTD. All rights reserved.
Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

9. Produced in partnership with The Royal London Hospital
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Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

10. Primary Indications Acute Kidney Injury Management of electrolytes
Fluid volume management
Small, middle, and large molecule removal targets
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11. CVVHD Continuous Veno-venous Haemodialysis
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12. Produced in partnership with The Royal London Hospital
Blood is circulated through a highly permeable haemofilter or dialyser via an extracorporeal circuit.
Water soluble small molecules diffuse out of the patients blood and into the dialysate solution, or out of the dialysate solution and into the patients
blood. e.g. electrolytes
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13. Produced in partnership with The Royal London Hospital
Diffusion
The movement of solutes across a semi-permeable membrane through a concentration gradient.
Water soluble small molecules are removed.
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14. Produced in partnership with The Royal London Hospital
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15. Produced in partnership with The Royal London Hospital
Primary Indications
Acute Kidney Injury
Management of electrolytes Fluid volume management Small molecule removal
targets
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16. CVVH Continuous Veno-Venous Haemofiltration
Produced in partnership with The Royal London Hospital
Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

17. Produced in partnership with The Royal London Hospital
Blood is circulated through a highly permeable haemofilter via an extracorporeal circuit.
Plasma water, small, middle, and large molecules
are pulled from the patients blood and into the waste/filtration bag by ultrafiltration and convection (solute drag).
Fluid is replaced into the patients blood at an equal or lower rate to achieve desired fluid loss.
Produced in partnership with The Royal London Hospital
Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

18. Convection The movement of fluid across a semi-permeable
membrane creating solute drag.
As fluid is pulled across the membrane water soluble
molecules dissolved in the fluid are taken with it.
Small, middle, and large molecules are removed.
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19. Produced in partnership with The Royal London Hospital
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20. Primary Indications Acute Kidney Injury
Management of electrolytes Fluid volume management Sepsis and septic shock
Small, middle, and large molecule removal targets
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21. Produced in partnership with The Royal London Hospital
TPE
Therapeutic Plasma Exchange
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22. Plasma, small, middle and large sized molecules are
Blood is circulated through a highly permeable plasmafilter via an extracorporeal circuit.
Plasma, small, middle and large sized molecules are
pulled from the patients blood and into the waste/filtration bag by ultrafiltration and convection. (solute drag)
Plasma is replaced into the patients blood at an equal
rate.
Produced in partnership with The Royal London Hospital
Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

23. Convection The movement of fluid across a semi-permeable
membrane creating solute drag.
As fluid is pulled across the membrane, some plasma
and other soluble components dissolved in the fluid
are taken with it.
Small, middle, and large molecules are removed.
Produced in partnership with The Royal London Hospital
Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

24. Produced in partnership with The Royal London Hospital
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25. Primary Indications Plasma replacement
Plasma supplementation Individual Clinical Presentations
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26. CVVH Continuous Veno-Venous Haemofiltration
Regional Citrate Anticoagulation
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27. Plasma water, small, middle, and large sized solutes
Blood is circulated through a highly permeable haemofilter via an extracorporeal circuit.
Plasma water, small, middle, and large sized solutes
are pulled from the patients blood and into the waste/filtration bag by ultrafiltration and convection. (solute drag)
Fluid is replaced into the patients blood at an equal
or lower rate to achieve desired fluid loss.
The extracorporeal circuit only is anticoagulated.
Produced in partnership with The Royal London Hospital
Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

28. Convection The movement of fluid across a semi-permeable
membrane creating solute drag.
As fluid is pulled across the membrane water soluble
molecules dissolved in the fluid are taken with it
Small, middle, and large molecules are removed.
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Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

29. Produced in partnership with The Royal London Hospital
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30. Primary Indications Acute Renal Failure
Management of electrolytes Management of fluid volume
Small, middle, and large molecule removal targets Regional Citrate Anticoagulation is available
Produced in partnership with The Royal London Hospital
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31. Produced in partnership with The Royal London Hospital
TPE
Therapeutic Plasma Exchange
Regional Citrate Anticoagulation
Produced in partnership with The Royal London Hospital
Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

32. Plasma is replaced into the patients blood at an equal rate.
Blood is circulated through a highly permeable plasmafilter via an extracorporeal circuit.
Plasma, small, middle, and large molecules are pulled from the patients blood and into the waste/filtration bag by ultrafiltration and convection. (solute drag)
Plasma is replaced into the patients blood at an equal
rate.
The extracorporeal circuit only is anticoagulated.
Produced in partnership with The Royal London Hospital
Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

33. Convection The movement of fluid across a semi-permeable
membrane creating solute drag.
As fluid is pulled across the membrane, some plasma
and other soluble components dissolved in the fluid
are taken with it.
Plasma, small, middle, and large molecules are
removed.
Produced in partnership with The Royal London Hospital
Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

34. Produced in partnership with The Royal London Hospital
Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

35. Primary Indications Plasma replacement
Plasma supplementation Individual Clinical Presentations
Regional Citrate Anticoagulation is available
Produced in partnership with The Royal London Hospital
Copyright ©2015 NIKKISO Co., LTD. All rights reserved.