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Figure 6 Metabolism of pterins

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1 Figure 6 Metabolism of pterins
Figure 6 | Metabolism of pterins. Tetrahydrobiopterin can be generated from GTP through a series of enzymatic steps. Tetrahydrobiopterin is a co-factor in a number of cellular reactions, and is oxidized to quinonoid dihydrobiopterin, which can be recycled by dihydropteridine reductase (DHPR), and to dihydrobiopterin, which is recycled by dihydrofolate reductase (DHFR). The latter enzyme is antagonized by methotrexate). Brown, P. M. et al. (2016) Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers Nat. Rev. Rheumatol. doi: /nrrheum

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