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Immunohistochemical detection of aquaporin expression in eutopic and ectopic endometria from women with endometriomas  Xiu-Xiu Jiang, M.D., Riu-Jin Wu,

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Presentation on theme: "Immunohistochemical detection of aquaporin expression in eutopic and ectopic endometria from women with endometriomas  Xiu-Xiu Jiang, M.D., Riu-Jin Wu,"— Presentation transcript:

1 Immunohistochemical detection of aquaporin expression in eutopic and ectopic endometria from women with endometriomas  Xiu-Xiu Jiang, M.D., Riu-Jin Wu, Ph.D., Kai-Hong Xu, M.D., Cai-Yun Zhou, B.S., Xiao-Yan Guo, M.D., Ya-Li Sun, M.D., Jun Lin, M.D.  Fertility and Sterility  Volume 94, Issue 4, Pages (September 2010) DOI: /j.fertnstert Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Immunohistochemistry of aquaporins (AQPs) in eutopic endometria. Representative negative immunostaining of AQPs in a midsecretory phase (control group) (A, E, I) and positive immunostaining in early proliferative phase (EP) (B, F, J), late proliferative phase (LP) (C, G, K), and secretory phase (SP) (D, H, L). Magnification ×200. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Immunohistochemistry of AQPs in ectopic endometria. Representative negative immunostaining of AQPs in a midsecretory phase (control group) (A, E, I) and positive immunostaining in EP (B, F, J), LP (C, G, K), and SP (D, H, L).Magnification ×200. Abbreviations as in Figure 1. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 Incidence of positive immunostaining of AQPs in various phases of the menstrual cycle. No significant difference in AQP-2, -5, and -8 expression in eutopic endometrium or in ectopic endometrium from women with endometriomas. PP = proliferative phase, SP = secretory phase. PP vs. SP in EuAQP-2: P=.768. PP vs. SP in EuAQP-5: P=.052. PP vs. SP in EuAQP-8: P=.299. PP vs. SP in EcAQP-2: P=.215. PP vs. SP in EcAQP-5: P=.091. PP vs. SP in EcAQP-8: P=.284. EcAQP=aquaporin expressed in ectopic endometrium; EuAQP=aquaporin expressed in eutopic endometrium; other abbreviations as in Figure 1. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

5 Figure 4 Comparison of AQP expression in 70 eutopic and ectopic endometrial tissues. Significant difference in AQP-2, -5, and -8 expression between eutopic and ectopic endometrium from women with endometriomas: EuAQP-2 vs. EcAQP-2: P<.001. EuAQP-5 vs. EcAQP-5: P=.004. EuAQP-8 vs. EcAQP-8: P=.001. Abbreviations as in Figures 1 and 4. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

6 Figure 5 Expression of aquaporins (AQP) 2, 5, and 8 in eutopic endometria (A–C) and ectopic endometria (D–F). Expression levels of endometrial AQP-2, -5, and -8 are lower in ectopic group than in eutopic group. Magnification v×400. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions


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