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Aggravated TSLP-Induced Atopic Dermatitis in Mice Lacking Dicer in Adult Skin Keratinocytes  Pierre Hener, Laetitia Friedmann, Daniel Metzger, Pierre.

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Presentation on theme: "Aggravated TSLP-Induced Atopic Dermatitis in Mice Lacking Dicer in Adult Skin Keratinocytes  Pierre Hener, Laetitia Friedmann, Daniel Metzger, Pierre."— Presentation transcript:

1 Aggravated TSLP-Induced Atopic Dermatitis in Mice Lacking Dicer in Adult Skin Keratinocytes 
Pierre Hener, Laetitia Friedmann, Daniel Metzger, Pierre Chambon, Mei Li  Journal of Investigative Dermatology  Volume 131, Issue 11, Pages (November 2011) DOI: /jid Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Increased thymic stromal lymphopoietin (TSLP) expression in MC903-treated Diceriep-/- skin. (a) Thymic stromal lymphopoietin (TSLP) RNA levels in ears, and (b) TSLP protein levels in ear extract at day 2 (D2) and D4 from control (CT) and Diceriep-/- mutant (MT) mice, topically treated with ethanol (EtOH, as vehicle control) or MC903 (1 nmol per day and per ear). Error bars indicate s.e.m. (n≥3). (c) Immunohistochemical (IHC) staining of TSLP on ear sections from MC903 topically treated CT (left panel) and MT (right panel) mice at D4 (with MC903 application at D1 and D2, 1 nmol per day and per ear). Methods are described in Supplementary Material online. White dashed lines indicate the dermal/epidermal junction. Yellow corresponds to staining of antibody, whereas blue corresponds to DAPI staining of nuclei. Bar=50 μm. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 Aggravated MC903-induced skin inflammation in Diceriep-/- mice. (a) Hematoxylin/eosin-stained sections of ears at day 8 (D8) or D12, from control (CT) and Diceriep-/- mutant (MT) mice, topically treated with ethanol (EtOH) or MC903. Bar=50 μm. (b) Immunohistochemical (IHC) staining of major basic protein (MBP, specific for eosinophils) on ear sections from MC903-treated CT and MT at day 12 (D12). Bar=50 μm. (c) Quantitative RT-PCR analyses of cytokine and chemokine mRNA levels in ears at D12. (d) Serum IgE levels of CT and MT mice at D8 and D12, treated with EtOH or MC903. Error bars indicate s.e.m. (n≥3). Methods are described in Supplementary Material online. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions

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