1. Phylogenetic analysis of 3,582 HAV isolates in the VP1/P2B region (315-bp fragment).
Phylogenetic analysis of 3,582 HAV isolates in the VP1/P2B region (315-bp fragment). The dendrogram (unweighted-pair group method using average linkages) was created by using Kimura's two-parameter model. Isolates were obtained from the United States (n = 2,190) and other parts of the world. The U.S. specimens included specimens from hepatitis A cases from CDC's Sentinel Counties Study of Acute Viral Hepatitis (11, 170), published and unpublished outbreak investigations (30, 63, 112), and others submitted to CDC for investigation. Specimens from the U.S.-Mexico Border Infectious Disease Surveillance (BIDS) project (258) were also included and represented cases primarily from the United States. Specimens from other countries include those from Mexico, Brazil, Israel, Jordan, Egypt, Moldova, and Kazakhstan and were submitted to CDC as part of outbreak or epidemiologic investigations. Sequences from GenBank (Italy, Norway, Spain, Tunisia, and Japan) were also included in the analysis. Only unique sequence patterns are shown in the tree. Genotypes and subgenotypes are indicated on the branches, and the geographical locations of case patients are indicated in different colors.
Omana V. Nainan et al. Clin. Microbiol. Rev. 2006; doi: /CMR