1. Michael G. Klein et al. JACEP 2016;j.jacep.2016.07.008
Voltage Dependence of hERG Current Blockade by Loperamide Human ether-à-go-go-related gene (hERG) currents in control (A) and 100 nmol/l loperamide (B, same cell) at increasing test depolarizations. The voltage pulse protocol is shown in the inset. Current-voltage relationships for the steady current (end of test depolarization, C) and the peak tail current (D) in control and 100 nmol/l loperamide. Points are mean ± SEM for 6 cells, normalized to the maximum of the control. In (D), the points are fitted to a Boltzmann function with the following parameters: control (blue line), V′ = −11.6 mV, k = 9.1 mV; loperamide (red line), IMax = 0.36, V′ = −29.9, k = 8.2 mV. The dashed red line is the same as the solid red line but scaled to 1.0 to show the relative changes of V′ and k compared with control.
Michael G. Klein et al. JACEP 2016;j.jacep
American College of Cardiology Foundation