1. MOLECULAR MECHANISMS OF AGING AND DRUG RESISTANCE
Systems Biology for Translational Medicine
Prospective Project Partnership Meeting
MOLECULAR MECHANISMS OF AGING AND DRUG RESISTANCE
Ayşe Banu DEMİR
Faculty of Medicine
Department of Basic Medical Sciences

2. Field of Study / Technical Experience
Keywords: Aging, Yeast, genome-wide screenings, Drug resistance, Cancer
General Information:
Yeast: Grade 1 model for genetic and genomic techniques
31% of proteins have human orthologues
50% of genes related to human diseases have yeast orthologues
6400 ORFs ready-to-use
S.cerevisiae

3. Projects
Completed:
Determination of the molecular damages due to the aging process in chronologically aged antioxidant mutants of S.cerevisiae (IYTE-Individual Project) ( )
Identification of doxorubicin drug resistance mechanisms by using genomic techniques (TUBİTAK-114Z701) ( )
Cisplatin ototoxicity and its relation to polymorphisms (DEU-BAP-2013.KB.SAG.049) ( )
Assessment of the molecular basis of Neuroblastoma: Can high-risk group be classified into ultra-high risk and high-risk subgroups? (DEU-BAP-2014.KB.SAG.016) ( )
Ongoing:
Identification of peroxiredoxins on life-span and vacuolar pH control (Individual project in collaboration with Gothenburg University)

4. Projects
Demir, A.B., PhD thesis, Jan. 2015

5. Projects
There exist some common pathways in drug resistance and longevity regulation
DIABETES, VOL. 61, JUNE 2012

6. Project Idea / Contribution Fields
Proposed project titles:
Detailed analysis of the role of membrane assymetry changes in cancer drug resistance
Development of new laboratory models for aging and age related diseases (organ-on-a-chip, microfluidic models)
List of the fields you may participate and/or techniques you may offer:
Genome-wide screenings in yeast model
Molecular biology techniques (Source: yeast cells, cell lines, tissue samples)
Proteomic analysis (including MALDI-TOF)

7. Dept. of Basic Medical Sciences E-mail: banu.demir@ieu.edu.tr
Contact Details
Ayşe Banu DEMİR
Faculty of Medicine
Dept. of Basic Medical Sciences