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Role of adipose tissue in the pathogenesis of cardiac arrhythmias

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Presentation on theme: "Role of adipose tissue in the pathogenesis of cardiac arrhythmias"— Presentation transcript:

1 Role of adipose tissue in the pathogenesis of cardiac arrhythmias
Rahul Samanta, MBBS, MRCP(UK), FRACP, Jim Pouliopoulos, BSc, MSc(Med), PhD, Aravinda Thiagalingam, MBBS, PhD, FRACP, Pramesh Kovoor, MB BS, PhD, FRACP  Heart Rhythm  Volume 13, Issue 1, Pages (January 2016) DOI: /j.hrthm Copyright © 2016 Heart Rhythm Society Terms and Conditions

2 Figure 1 Right ventricular endomyocardial biopsy demonstrates fatty (*) and fibrous (†) infiltration in a patient with arrhythmogenic right ventricular cardiomyopathy (Gomori trichrome stain). Heart Rhythm  , DOI: ( /j.hrthm ) Copyright © 2016 Heart Rhythm Society Terms and Conditions

3 Figure 2 Myocardial biopsy in the ovine model of chronic myocardial infarction. A: Fatty (*) and fibrous infiltration (†) (Gomori trichrome staining). B: Presence of neutral lipid (‡) (oil red-O staining). C: Connexin43 (Cx43) expression at the scar interface (light fluorescence microscopy). D: Myocardium from within scar exhibiting mixed lateralized and intercalated disk expression of Cx43 at myocyte junctions. E: Myocardium, remote from the infarct zone, showing normal cellular organization and expression of Cx43 at the intercalated disks of myocytes. Heart Rhythm  , DOI: ( /j.hrthm ) Copyright © 2016 Heart Rhythm Society Terms and Conditions

4 Figure 3 Right ventricular endomyocardial biopsy demonstrating significant fatty infiltration (*) in a patient with myotonic dystrophy (hematoxylin–eosin stain).65 Heart Rhythm  , DOI: ( /j.hrthm ) Copyright © 2016 Heart Rhythm Society Terms and Conditions

5 Figure 4 Right ventricular endomyocardial biopsy showing glycolipid inclusion vacuoles (black arrows) in a patient with Fabry disease (hematoxylin–eosin stain). Heart Rhythm  , DOI: ( /j.hrthm ) Copyright © 2016 Heart Rhythm Society Terms and Conditions


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