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Proteasome Inhibitors and Patients

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Presentation on theme: "Proteasome Inhibitors and Patients"— Presentation transcript:

1 Proteasome Inhibitors and Patients

2

3 RRMM Overview

4 Multiple Treatment Options Are Available for RRMM

5 Proteasome Inhibitors: Key Characteristics

6 ESMO Practice Guidelines: RRMM

7 Type of Relapse May Influence Treatment Decisions

8 Efficacy of Ixazomib in Patients With RRMM and High-Risk Cytogenetics: TOURMALINE-1 Trial

9 Choice of Proteasome Inhibitor at Relapse Depends on Multiple Factors

10 Patient Profile 1: Young and Fit

11 Prolonged Exposure to Proteasome Inhibitors Is Associated With Improved Outcomes

12 Duration of Exposure to IRd in the Phase 3 TOURMALINE-1 Trial

13 Weekly vs Twice Weekly Administration of Carfilzomib in RRMM: Phase 3 ARROW Trial

14 Bortezomib Maintenance Therapy Improves Depth of Response After ASCT

15 Ongoing Phase 3 Trials of Ixazomib as Maintenance Therapy

16 Patient Profile 2: Old and Frail

17 Safety Comparison of IRd vs Rd: Phase 3 TOURMALINE-1 Trial

18 Patient Profile 3: Comorbidities

19 Patient Profile 4: Disease-Related Factors

20 Selecting an Appropriate Treatment for the Patient With RRMM

21 Closing Remarks

22 Abbreviations

23 Abbreviations (cont)


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