3. Etiology and Incidence

4. Pathophysiology Hemophilia is due to a defect in thrombin generation on the platelet surface

5. Pathophysiology (cont) Hemophilia is due to a defect in thrombin generation on the platelet surface

6. Clinical Presentation

7. Potential Clinical Sequelae of Poorly Managed Hemophilia

8. Clinical Classification

9. Primary Therapy Clotting Factor Replacement

10. Prophylaxis Protocols Definitions

11. Prophylaxis Some Related Questions

13. Joint Outcome Study Results

14. Prophylaxis in Adolescents and Adults SPINART Study

15. SPINART Results

16. Prophylaxis* Initiation and Dosing

17. Inhibitors

19. Adherence to Prophylaxis (cont)

20. HTCs

21. HTC vs non-HTC Effect on Mortality

22. Extended Half-Life Clotting Factor Formulations

23. Optimizing Hemophilia Management Through Individualized Treatment

24. Assessment of Joint Health Hemophilia Joint Health Scores

25. Summary

26. Abbreviations

27. References

28. References

29. References

30. References

31. References