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A “No-wash” Albumin-Dextran Dilution Strategy for Cord Blood Unit Thaw: High Rate of Engraftment and a Low Incidence of Serious Infusion Reactions  Juliet.

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Presentation on theme: "A “No-wash” Albumin-Dextran Dilution Strategy for Cord Blood Unit Thaw: High Rate of Engraftment and a Low Incidence of Serious Infusion Reactions  Juliet."— Presentation transcript:

1 A “No-wash” Albumin-Dextran Dilution Strategy for Cord Blood Unit Thaw: High Rate of Engraftment and a Low Incidence of Serious Infusion Reactions  Juliet N. Barker, Michelle Abboud, Robert D. Rice, Rebecca Hawke, Allison Schaible, Glenn Heller, Vincent La Russa, Andromachi Scaradavou  Biology of Blood and Marrow Transplantation  Volume 15, Issue 12, Pages (December 2009) DOI: /j.bbmt Copyright © Terms and Conditions

2 Figure 1 Distribution of infused DMSO doses/kg with double-unit CB grafts prepared with albumin dilution and incidence of infusion reactions in 53 patients. To most accurately represent the DMSO dose with two unwashed units the single patient who received 1 washed unit is excluded from this analysis. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions

3 Figure 2 Cumulative incidence of sustained neutrophil engraftment (A) and platelet engraftment (B) after CBT with double-unit grafts prepared with albumin-dextran dilution. Recipients of ablative and nonmyeloablative conditioning are shown separately. Although early recovery in recipients of nonmyeloablative conditioning resulted from transient autologous recovery, all engrafting patients shown converted to sustained donor-derived hematopoiesis. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions

4 Figure 3 Kaplan-Meier probabilities of OS and DFS after CBT with double unit grafts prepared with albumin-dextran dilution. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions


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