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Dylan R. Nieman, MD, PhD, Christian G. Peyre, MD, Thomas J

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Presentation on theme: "Dylan R. Nieman, MD, PhD, Christian G. Peyre, MD, Thomas J"— Presentation transcript:

1 Neoadjuvant Treatment Response in Negative Nodes Is an Important Prognosticator After Esophagectomy 
Dylan R. Nieman, MD, PhD, Christian G. Peyre, MD, Thomas J. Watson, MD, Wenqing Cao, MD, Michael D. Lunt, MD, Michal J. Lada, MD, Michelle S. Han, MD, Carolyn E. Jones, MD, Jeffrey H. Peters, MD  The Annals of Thoracic Surgery  Volume 99, Issue 1, Pages (January 2015) DOI: /j.athoracsur Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Histologic evidence of lymph node treatment effect. Representative hematoxylin and eosin–stained lymph nodes (magnification ×40) with histologic evidence of prior cancer involvement, including (A) calcification and necrosis, (B) central fibrosis, or (C) acellular mucin. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Survival curve by nodal status: no evidence of nodal disease at any time (negative, solid line), treatment-response nodes (TRN) with evidence of prior nodal involvement but without viable cancer cells detected (dashed line) or with evidence of active nodal malignancy (positive, dashed-dot line). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Survival curves (A) by stage using the traditional American Joint Committee on Cancer staging criteria, (B) by stage (0-1, solid line; 2, dashed line; 3, dash-dot line) counting treatment-response nodes (TRN) as involved nodes, (C) in patients with no or limited nodal involvement (N0 or N1), comparing patients with (dashed line) and without (solid line) TRN-positive nodes, and (D) in patients with limited stage disease (0-2B) comparing patients with (dashed line) and without (solid line) TRNs. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions


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