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Histologic Transformation in NSCLC with PD-1 therapy

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Presentation on theme: "Histologic Transformation in NSCLC with PD-1 therapy"— Presentation transcript:

1 Histologic Transformation in NSCLC with PD-1 therapy
Misako Nagasaka, MD, Rahul S. Pansare, MD, Eman Abdulfatah, MD, Hui Guan, MD, Paul Tranchida, MD, Shirish M. Gadgeel, MD  Journal of Thoracic Oncology  Volume 12, Issue 9, Pages e133-e134 (September 2017) DOI: /j.jtho Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 (A and B) Original T3 vertebrae laminectomy specimen. Rare intercellular bridges was seen, which supports the diagnosis of squamous cell carcinoma based on morphologic findings. Because of decalcification, tumor cells lost antigenicity and tested negative for lung adenocarcinoma cocktail (the results of testing for thyroid transcription factor 1 and napsin A were negative) and negative for squamous cell carcinoma cocktail (cytokeratin 5/6 and protein 63). Journal of Thoracic Oncology  , e133-e134DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 (A and B) Biopsy specimen from the right upper lobe. Tumor cells show focal glandular differentiation (A), which supports adenocarcinoma morphologically. The tumor cells tested positive for thyroid transcription factor 1 focally (B), supporting the diagnosis of adenocarcinoma of lung primary. Journal of Thoracic Oncology  , e133-e134DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

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