1. Patient-Reported Outcomes Following Treatment of Chronic Hepatitis C Virus Infection With Sofosbuvir and Velpatasvir, With or Without Voxilaprevir 
Zobair M. Younossi, Maria Stepanova, Stuart Gordon, Stefan Zeuzem, Michael P. Mann, Ira Jacobson, Marc Bourliere, Curtis Cooper, Steven Flamm, K. Rajender Reddy, Kris Kowdley, Issah Younossi, Sharon Hunt 
Clinical Gastroenterology and Hepatology 
Volume 16, Issue 4, Pages e6 (April 2018)
DOI: /j.cgh
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2. Figure 1
Patient-reported outcomes in POLARIS-1 and -4 (SOF/VEL: N = 151; SOF/VEL/VOX: N = 445; Placebo: N = 151). (A) Physical component summary of SF-36. (B) Mental component summary of SF-36. (C) Fatigue scale of FACIT-F. (D) Total CLDQ-HCV score. (E) Work productivity impairment of WPAI:SHP. (F) Activity impairment of WPAI:SHP.
Clinical Gastroenterology and Hepatology  , e6DOI: ( /j.cgh )
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3. Figure 2
Mean treatment-emergent changes in summary PROs by (A) the end of treatment and (B) post-treatment week 4 (SOF/VEL: N = 151; SOF/VEL/VOX: N = 445; Placebo: N = 151). All PRO domains are shown in Supplementary Figure 1. All changes are shown on a 0–100 scale.
Clinical Gastroenterology and Hepatology  , e6DOI: ( /j.cgh )
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4. Figure 3
Mean post-treatment changes in summary PROs by (A) post-treatment week 12 and (B) post-treatment week 24 in patients with SVR (SOF/VEL: N = 136; SOF/VEL/VOX: N = 431). All PRO domains are shown in Supplementary Figure 2. All changes are shown on a 0–100 scale.
Clinical Gastroenterology and Hepatology  , e6DOI: ( /j.cgh )
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5. Figure 4
Independent association of receiving active treatment (vs placebo) with summary PROs after adjustment for demographics, clinical PRO predictors, and baseline PRO levels (summarized in Supplementary Table 3) (N = 596 with active treatment vs N = 152 with placebo). (A) End of treatment. (B) Post-treatment week 4. All betas are shown on a 0–100 scale.
Clinical Gastroenterology and Hepatology  , e6DOI: ( /j.cgh )
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6. Supplementary Figure 1
Mean treatment-emergent changes in summary PROs by (A) the end of treatment and (B) post-treatment week 4. All changes are shown on a 0–100 scale.
Clinical Gastroenterology and Hepatology  , e6DOI: ( /j.cgh )
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7. Supplementary Figure 2
Mean post-treatment changes in summary PROs by (A) post-treatment week 12 and (B) post-treatment week 24. All changes are shown on a 0–100 scale.
Clinical Gastroenterology and Hepatology  , e6DOI: ( /j.cgh )
Copyright © 2018 AGA Institute Terms and Conditions

8. Supplementary Figure 3
End of treatment mean changes in PROs in patients (A) with and without cirrhosis, (B) low baseline CLDQ-HCV (<4.5).
Clinical Gastroenterology and Hepatology  , e6DOI: ( /j.cgh )
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