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Twenty Years of Unrelated Donor Bone Marrow Transplantation for Pediatric Acute Leukemia Facilitated by the National Marrow Donor Program  Margaret L.

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Presentation on theme: "Twenty Years of Unrelated Donor Bone Marrow Transplantation for Pediatric Acute Leukemia Facilitated by the National Marrow Donor Program  Margaret L."— Presentation transcript:

1 Twenty Years of Unrelated Donor Bone Marrow Transplantation for Pediatric Acute Leukemia Facilitated by the National Marrow Donor Program  Margaret L. MacMillan, Stella M. Davies, Gene O. Nelson, Pintip Chitphakdithai, Dennis L. Confer, Roberta J. King, Nancy A. Kernan  Biology of Blood and Marrow Transplantation  Volume 14, Issue 9, Pages (September 2008) DOI: /j.bbmt Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Number of pediatric transplants facilitated by the NMDP, by year and stem cell source. Biology of Blood and Marrow Transplantation  , 16-22DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Probability of survival after unrelated donor for children with acute leukemia, by transplant period. P-value at 2 years <.001. Biology of Blood and Marrow Transplantation  , 16-22DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 (A) Probability of survival after unrelated donor BMT for children with acute leukemia in first complete remission (CR1) at time of transplant, by transplant period. P-value at 2 years <.001. (B) Probability of survival after unrelated donor BMT for children with acute leukemia in second complete remission (CR2) at time of transplant, by transplant period. P-value at 2 years = .001. Biology of Blood and Marrow Transplantation  , 16-22DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Cumulative incidence of TRM in children with acute leukemia in CR1 or CR2 at the time of BMT, by transplant period. P-value <.001. Biology of Blood and Marrow Transplantation  , 16-22DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

6 Figure 5 (A) Probability of survival after HLA well-matched unrelated donor BMT for children with acute leukemia, by transplant period. P-value at 2 years <.001. (B) Probability of survival after HLA mismatched unrelated donor BMT for children with acute leukemia, by transplant period. P-value at 2 years = .008. Biology of Blood and Marrow Transplantation  , 16-22DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

7 Figure 6 Probability of survival after unrelated donor BMT in 2003 to 2006 for children with acute leukemia, by disease state at time of transplant. P-value at 2 years <.001 for ALL, =.007 for AML. Biology of Blood and Marrow Transplantation  , 16-22DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

8 Figure 7 Probability of survival after unrelated donor BMT for children with SAA by transplant period. Dataset includes additional recipients with non-myeloablative conditioning regimens. Pointwise P-value at 2 years <.001. Biology of Blood and Marrow Transplantation  , 16-22DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

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