1. The effects of general anaesthetics on ligand-gated ion channels
J.P. Dilger 
British Journal of Anaesthesia 
Volume 89, Issue 1, Pages (July 2002)
DOI: /bja/aef161
Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

2. Fig 1
The structure of ligand-gated ion channels. (a) Structure of the cys-loop superfamily. (b) Structure of the ionotropic glutamate receptor family. (c) Structure of the P2X family of ATP-gated channels.
British Journal of Anaesthesia  , 41-51DOI: ( /bja/aef161)
Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

3. Fig 2
Kinetic schemes used to describe activation and desensitization in ligand-gated ion channels. See text for details. (a) General scheme for ligand-gated channels with two agonist binding sites. (b) The behaviour of mnAChR channels is well described by this part of the general scheme. (c) GABAAR channels have been successfully modelled by this part of the general scheme.
British Journal of Anaesthesia  , 41-51DOI: ( /bja/aef161)
Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

4. Fig 3
A kinetic scheme used to describe inhibition of the mnAChR channel by anaesthetics. See text for details.
British Journal of Anaesthesia  , 41-51DOI: ( /bja/aef161)
Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

5. Fig 4
A kinetic scheme used to describe potentiation of the GABAAR channel by anaesthetics. See text for details.
British Journal of Anaesthesia  , 41-51DOI: ( /bja/aef161)
Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

6. Fig 5
Current simulations illustrating the time-dependence of current modulation by an anaesthetic that has two effects on a channel. The control current desensitizes with a time constant (τ) of 0.5 s. For current test 1, the anaesthetic is assumed to decrease the peak amplitude by 50% and increase the rate of desensitization by a factor of 2 (τ=0.25 s). For current test 2, the anaesthetic is also assumed to decrease the peak amplitude by 50% but to decrease the rate of desensitization by a factor of 2 (τ=1 s). The ratio of test to control is shown in the inset on a logarithmic scale. The degree of inhibition or potentiation observed is critically dependent on the time resolution of the experiment (the first time point that can be measured).
British Journal of Anaesthesia  , 41-51DOI: ( /bja/aef161)
Copyright © 2002 British Journal of Anaesthesia Terms and Conditions