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Assessment of Consistency of Fixed Airflow Obstruction Status during Budesonide/Formoterol Treatment and Its Effects on Treatment Outcomes in Patients.

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Presentation on theme: "Assessment of Consistency of Fixed Airflow Obstruction Status during Budesonide/Formoterol Treatment and Its Effects on Treatment Outcomes in Patients."— Presentation transcript:

1 Assessment of Consistency of Fixed Airflow Obstruction Status during Budesonide/Formoterol Treatment and Its Effects on Treatment Outcomes in Patients with Asthma  Donald P. Tashkin, MD, Gary E. Moore, MS, Frank Trudo, MD, Michael DePietro, MD, Bradley E. Chipps, MD  The Journal of Allergy and Clinical Immunology: In Practice  Volume 4, Issue 4, Pages (July 2016) DOI: /j.jaip Copyright © 2016 The Authors Terms and Conditions

2 Figure 1 Distribution of FAO status throughout the treatment period. BUD, Budesonide; FAO, fixed airflow obstruction; FM, formoterol. The Journal of Allergy and Clinical Immunology: In Practice 2016 4, DOI: ( /j.jaip ) Copyright © 2016 The Authors Terms and Conditions

3 Figure 2 Withdrawals due to PAEs in patients with (A) persistent FAO−, (B) persistent FAO+, and (C) inconsistent FAO. BUD, Budesonide; FAO, fixed airflow obstruction; FM, formoterol; PAEs, predefined worsening asthma events; PBO, placebo. The Journal of Allergy and Clinical Immunology: In Practice 2016 4, DOI: ( /j.jaip ) Copyright © 2016 The Authors Terms and Conditions

4 Figure 3 Predose FEV1 improvements in L by treatment and FAO status. Baseline was defined as the predose FEV1 value measured on the day of randomization (visit 2) or the screening predose value, if no value was available at visit 2. bid, Twice daily; BUD, budesonide; FAO, fixed airflow obstruction; FEV1, forced expiratory volume (L) in 1 second; FM, formoterol. The Journal of Allergy and Clinical Immunology: In Practice 2016 4, DOI: ( /j.jaip ) Copyright © 2016 The Authors Terms and Conditions

5 Figure 4 Percentage of responders with a ≥0.5 inh/d decrease in rescue medication use by treatment and FAO status. A decrease in rescue medication use was defined as the change from baseline (mean of all values during the run-in period) to mean value during the treatment period. bid, Twice daily; BUD, budesonide; FAO, fixed airflow obstruction; FM, formoterol; inh/d, inhalations per day. The Journal of Allergy and Clinical Immunology: In Practice 2016 4, DOI: ( /j.jaip ) Copyright © 2016 The Authors Terms and Conditions

6 Figure 5 Mean change in percentage of asthma control days by treatment and FAO status. An increase in the percentage of asthma control days was defined as the mean change from baseline (mean of all run-in period values) over the double-blind treatment period. bid, Twice daily; BUD, budesonide; FAO, fixed airflow obstruction; FM, formoterol. The Journal of Allergy and Clinical Immunology: In Practice 2016 4, DOI: ( /j.jaip ) Copyright © 2016 The Authors Terms and Conditions

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