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This Month in Gastroenterology

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Presentation on theme: "This Month in Gastroenterology"— Presentation transcript:

1 This Month in Gastroenterology
Jan Tack, John M. Carethers  Gastroenterology  Volume 135, Issue 3, Pages (September 2008) DOI: /j.gastro Copyright © 2008 AGA Institute Terms and Conditions

2 Figure 1 Time lag between peak longitudinal and circular muscle contractions during baseline, after administration of edrophonium in normal subjects and during control, after 5 and 10 μg/kg of atropine in subjects with nutcracker esophagus. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions

3 Figure 2 (A) Ascitic fluid lactoferrin levels (logarithmic scale) in samples with or without spontaneous bacterial peritonitis (SBP). (B) Receiver operating characteristic curve for ascitic fluid lactoferrin concentrations in ascitic fluid samples. AUC, area under the curve; CI, confidence interval. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions

4 Figure 3 A2BAR−/− mice are resistant to the development of DSS-induced colitis. Animals were killed after 6 days of treatment. (D) Histologic assessment is represented as histologic score. Data were expressed as mean values ± SE for the group compared (wild-type [WT] + DSS and A2BAR−/− + DSS). *P < (E) Myeloperoxidase (MPO) was measured as an index of neutrophil infiltration into the injured tissue. Each bar represents the mean value ± SE (n = 5; P < .002). (F) Colonic tissue culture supernatants were processed for keratinocyte-derived chemokine (KC) secretion. KC levels in WT mice treated with DSS are significantly higher compared with A2BAR−/− mice treated with DSS (P < .01). Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions

5 Figure 4 AR effect on hepatocarcinogenesis. (A) HCC incidence in mice. Intraperitoneal injections of 20 mg/kg/mice of DEN were made into 12-day-old mouse pups. After various time periods, mice were killed and tumor formation observed. Mice were considered positive if tumors were visible to the naked eye. (B) Tumor foci in 36-week-old DEN-induced male mice (P < .05). (C) Liver weight/body weight ratio in 36-week-old DEN-induced male mice (P < .05). T-AR−/y, total knockout in whole body; L-AR−/y, liver-specific knockout. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions


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