1. 3 to 4 million patients fit the entry criteria
Multicenter Autonomic Defibrillator Implantation Trial II (MADIT II): Background
MADIT & Multicenter Unsustained Tachycardia Trial (MUSTT): Demonstrated a benefit from ICD implantation in patients with CAD, reduced ventricular function, unsustained ventricular tachycardia, and inducible ventricular tachycardia on EP testing.
In MADIT II: No EP study required, inclusion criteria included a prior MI at least 30 days previous to implantation, and EF of 30% or less.
MADITT randomized 1232 patients from 71 US centers and 5 European centers to receive either an ICD, or to continue on conventional medical therapy
3 to 4 million patients fit the entry criteria
400,000 new cases annually

2. Multicenter Autonomic Defibrillator Implantation Trial II (MADIT II)
2,118 patients with anterior infarction, double blind randomized trial
High Dose Adenosine
70 µg/kg/min for 3 (n
Low Dose Adenosine
50 µg/kg/min for 3 hours
Placebo + + +
Thrombolysis or PCI
Thrombolysis or PCI
Thrombolysis or PCI
Infarct Size 120 –168 hours
Death/CHF at 6 months