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Γ-Aminobutyric acid (GABA) a and b receptors mediate the stimulatory effects of GABA on the human sperm acrosome reaction: interaction with progesterone 

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Presentation on theme: "Γ-Aminobutyric acid (GABA) a and b receptors mediate the stimulatory effects of GABA on the human sperm acrosome reaction: interaction with progesterone "— Presentation transcript:

1 γ-Aminobutyric acid (GABA) a and b receptors mediate the stimulatory effects of GABA on the human sperm acrosome reaction: interaction with progesterone  Aldo E Calogero, M.D., Nunziatina Burrello, Ph.D., Emanuela Ferrara, M.D., Jenny Hall, Ph.D., Simon Fishel, Ph.D., Rosario D’Agata, M.D.  Fertility and Sterility  Volume 71, Issue 5, Pages (May 1999) DOI: /S (99)

2 FIGURE 1 Effects of γ-aminobutyric acid (GABA) on the acrosome reaction of human spermatozoa obtained from 10 normozoospermic subjects. ∗P<.05 (vs. 0); †P<.05 (vs. GABA 1 μM); ‡P<.05 (vs. GABA 10 μM). Fertility and Sterility  , DOI: ( /S (99) )

3 FIGURE 2 Effects of bicuculline (BICU) (n = 12), a GABAA receptor antagonist (upper panel), or saclofen (SACL) (n = 9), a GABAB receptor antagonist (lower panel), on the spontaneous acrosome reaction of human spermatozoa and in response to 10 μM of γ-aminobutyric acid (GABA). ∗P<.05 (vs. no-treatment control); †P<.05 (vs. GABA 10 μM). Fertility and Sterility  , DOI: ( /S (99) )

4 FIGURE 3 Effects of increasing concentrations of progesterone on the acrosome reaction of human spermatozoa obtained from eight normozoospermic subjects. ∗P<.05 (vs. 0); †P<.05 (vs. progesterone 10 μM); ‡P<.05 (vs. progesterone 30 μM). Fertility and Sterility  , DOI: ( /S (99) )

5 FIGURE 4 Effects of the GABAA receptor antagonist bicuculline (BICU) on the progesterone (Prog)–stimulated acrosome reaction of human spermatozoa obtained from 10 normozoospermic subjects. ∗P<.05 (vs. 0); †P<.05 (vs. progesterone alone). Fertility and Sterility  , DOI: ( /S (99) )


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