1. Determination of HSP parameters in a HT workflow for Optimization of Solubility problems
Daily challenges in formulation work are related to solubility:
improved solubility might be achieved by a different solvent or
additional co-solvent or solvents need to have specific properties
Stable dispersions of solids need the right dispersants
organic coatings need to be resistant against certain solvents.
Permeation or diffusion of one material in another matrix
(polymer, human skin, …)
Approach:
One proven, powerful method for understanding solubility is the use of Hansen Solubility Parameters ( and In the Hansen solubility approach the total cohesive energy of a liquid is divided into three separate parts, quantitatively describing i) the non-polar or atomic (dispersion) interactions, ii) the permanent dipole permanent dipole interactions, and iii) the hydrogen bonding (electron interchange) interactions. These 3 values provide a means of predicting whether one material will dissolve in another and form a solution.
We can experimentally determine HSP parameters for a wide range of unknown materials: solids (fillers, pigments etc.), polymers and complex solutions : We have implemented the multiple solution approach in a high throughput workflow, making use of a relevant subset out of the original library of 88 test solutions. The workflow comprises precise formulation, mixing and analytical measurement of solubility (not just “by the eye”). The HSP parameters of the material are derived from the solubility results in up to 58 test solutions in a fast, correct and cost efficient way.
Solution:
We deliver the HSP data in a spreadsheet that is ready-to-import into your HSPiP. Or we can also help you to apply the HSP solubility data to your case - in order to solve your solubility or formulation question.