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Figure 1 Study flow diagram and definition of clinical response

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1 Figure 1 Study flow diagram and definition of clinical response
Figure 1 Study flow diagram and definition of clinical response. The diagram outlines the progress of enrolled ... Figure 1 Study flow diagram and definition of clinical response. The diagram outlines the progress of enrolled patients in the study. BiV, biventricular; MPP, MultiPoint™ pacing. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( Eur Heart J, ehz109, The content of this slide may be subject to copyright: please see the slide notes for details.

2 Figure 2 Kaplan–Meier estimates of time to heart failure event from implant through 6-month randomization. A heart ... Figure 2 Kaplan–Meier estimates of time to heart failure event from implant through 6-month randomization. A heart failure event was defined as a hospitalization or emergency department visit for HF of ≥24 h, or hospitalization or emergency department visit for heart failure of <24 h requiring the intravenous administration of inotropes or diuretics. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( Eur Heart J, ehz109, The content of this slide may be subject to copyright: please see the slide notes for details.

3 Figure 3 Non-responder to responder conversion rate: study primary endpoint. The graph displays the proportion of ... Figure 3 Non-responder to responder conversion rate: study primary endpoint. The graph displays the proportion of patients converted from non-responders at 6 months to responders at 12 months between the two arms (MultiPoint™ pacing and biventricular). Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( Eur Heart J, ehz109, The content of this slide may be subject to copyright: please see the slide notes for details.

4 Figure 4 Effect of MultiPoint™ pacing programming on the study endpoint in pre-defined subgroups. The graph displays ... Figure 4 Effect of MultiPoint™ pacing programming on the study endpoint in pre-defined subgroups. The graph displays the non-responder to responder conversion rate difference between MultiPoint™ pacing and biventricular. The subgroups of left bundle branch block, non-left bundle branch block, ischaemic, non-ischaemic, QRS <150 ms, QRS ≥150 ms, New York Heart Association II, New York Heart Association II/III, left ventricular ejection fraction <25%, left ventricular ejection fraction ≥25%, LVEDV < median, and LVEDV ≥ median according to the baseline characteristics of the patients are included in the analyses. LVEDV, left ventricular end-systolic volume. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( Eur Heart J, ehz109, The content of this slide may be subject to copyright: please see the slide notes for details.

5 Figure 5 Non-responder to responder conversion rate: subgroup analysis
Figure 5 Non-responder to responder conversion rate: subgroup analysis. The graph displays the proportion of patients ... Figure 5 Non-responder to responder conversion rate: subgroup analysis. The graph displays the proportion of patients converted from non-responders at 6 months to responders at 12 months among three groups (MultiPoint™ Pacing—anatomical separation, MultiPoint™ Pacing—other programmed settings, and biventricular). BiV, biventricular; MPP-AS, MultiPoint™ pacing—anatomical separation/minimal intraventricular and interventricular timing delays; MPP-Other, MultiPoint™ Pacing—other programmed settings. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( Eur Heart J, ehz109, The content of this slide may be subject to copyright: please see the slide notes for details.

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