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Phenotypes and body mass in women with polycystic ovary syndrome identified in referral versus unselected populations: systematic review and meta-analysis 

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Presentation on theme: "Phenotypes and body mass in women with polycystic ovary syndrome identified in referral versus unselected populations: systematic review and meta-analysis "— Presentation transcript:

1 Phenotypes and body mass in women with polycystic ovary syndrome identified in referral versus unselected populations: systematic review and meta-analysis  Daria Lizneva, M.D., Ph.D., Richard Kirubakaran, Ph.D., Kateryna Mykhalchenko, M.D., Larisa Suturina, M.D., Ph.D., Galina Chernukha, M.D., Ph.D., Michael P. Diamond, M.D., Ricardo Azziz, M.D., M.P.H.  Fertility and Sterility  Volume 106, Issue 6, Pages e2 (November 2016) DOI: /j.fertnstert Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Pooled prevalences of the PCOS phenotypes for unselected (n = 9) and referral (n = 34) populations: phenotype A (clinical and/or biochemical HA + OA + PCOM). Referral 50% (95% CI, 46%–54%, I2 = 94.70); unselected 19% (95% CI, 13%–27%, I2 = 87.08); subgroup difference P<.001. Fertility and Sterility  , e2DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Pooled prevalences of the PCOS phenotypes for unselected (n = 9) and referral (n = 34) populations: phenotype B (clinical and/or biochemical HA + OA). Referral 13% (95% CI, 11%–17%, I2 = 96.21); unselected 25% (95% CI, 15%–37%, I2 = 93.25); subgroup difference P=.026. Fertility and Sterility  , e2DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 Pooled prevalences of the PCOS phenotypes for unselected (n = 9) and referral (n = 34) populations: phenotype C (clinical and/or biochemical HA + PCOM). Referral 14% (95% CI, 12%–16%, I2 = 91.37); unselected 34% (95% CI, 25%–46%, I2 = 90.75); subgroup difference P<.001. Fertility and Sterility  , e2DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

5 Figure 4 Pooled prevalences of the PCOS phenotypes for unselected (n = 9) and referral (n = 34) populations: phenotype D (OA + PCOM). Referral 17% (95% CI, 13%–22%, I2 = 97.39); unselected 19% (95% CI, 14%–25%, I2 = 78.31); subgroup difference P=.625. Fertility and Sterility  , e2DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

6 Supplemental Figure 1 Flow chart for systematic review and meta-analysis search methodology. Fertility and Sterility  , e2DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

7 Supplemental Figure 2 Meta-analysis for the standardized difference in means for BMI in unselected versus referral population. Fertility and Sterility  , e2DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions


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