1. AGING & CANCER

3. Gene loss
DNA Repair
Proteasome
telomare
STOP CYCLE/AGING
ENVIRONMENTAL STRESS
mutation
silencing and expressing gene
CANCER

4. Aging as a catabolic malfunction and “Garbage Catastrophe”
Young and clean
Old and Dirty
Oxidative damage
Oxidative damage
Proteosomal degradation
Proteosomal degradation
“Garbage catastrophe”
Oxidized and cross-linked proteins (Lipofuscin)‏
Oxidized and cross-linked proteins
Anti-aging Reversing the catastrophe

6. Gene loss
DNA Repair
Proteasome
telomare
STOP CYCLE/AGING
ENVIRONMENTAL STRESS
mutation
silencing and expressing gene
CANCER

7. ENVIRONMENTAL FACTOR
Nutrition excess calories cancers of colon, rectum, stomach, breast, ovaries
excess fat consumtion
obesity
cigaretes 1/3 of cancer deaths Cancers of lung, pancreas, mouth, larynx, liver,
alchohol esophagus and bladder
occupation 5% of cancerdeaths cancers of lung, bladder, stomach, blood, liver,
bones, skin
Radiation 3% /xray, uv, isotop blood and skin
Other drug, virus, bacteri various

9. Normal and Cancer cells contrast in their proliferation capacityVs
Normal cells
Cancer cells
Limited number of divisions
Unlimited number of divisions
Permanent growth arrest/senescence
Tumor

10. CANCER NEED MORE ENERGY

12. environmental stress
healty nutrient/suplement
HSF, HO-1, NOS, P45OR (GENE PROTECTOR)‏
necrotic
p53, HSF
repair mechanism, protecting cell
Apoptosis
Cancer
interaction of genes between stressor and food cause cancer