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Giant Alveolar Adenoma Causing Severe Dyspnoea

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1 Giant Alveolar Adenoma Causing Severe Dyspnoea
Francesco Petrella, MD, Stefania Rizzo, MD, Giuseppe Pelosi, MD, Alessandro Borri, MD, Domenico Galetta, MD, PhD, Roberto Gasparri, MD, Piergiorgio Solli, MD, PhD, Giulia Veronesi, MD, Lorenzo Spaggiari, MD, PhD  Journal of Thoracic Oncology  Volume 5, Issue 7, Pages (July 2010) DOI: /JTO.0b013e3181d95ca5 Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Posteroanterior (A) and lateral (B) x-ray views show a large cystic lesion in the middle-lower field of the left lung, with multiple intralesional septa and well-defined peripheral margins, displacing the lower lobe and the upper part of the upper lobe. Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181d95ca5) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Axial computed tomography (A) image and postprocessed reconstructed coronal (B) and sagittal (C) views of the lungs confirmed the presence of a 98-mm multiseptated cystic lesion arising from the lingula, characterized by well-defined walls and thin intralesional septa. Other findings were unremarkable. Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181d95ca5) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Gross pathology of the tumor showing a multiseptated giant cystic mass with thin, translucent walls. Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181d95ca5) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 Giant alveolar adenoma with large ectatic dilations (A), but the typical dual cell composition of type II pneumocytes and elongated septal mesenchymal cells (B), the former being positive for thyroid transcription factor-1 (C). The proliferative activity as assessed by Ki-67 immunostaining was negligible in both cell components (D). Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181d95ca5) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

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