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Double-Stranded RNA Sensing Determines Epithelial Cell Identity

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1 Double-Stranded RNA Sensing Determines Epithelial Cell Identity
Chung-Ping Liao, Edem Tchegnon, Lu Q. Le  Journal of Investigative Dermatology  Volume 139, Issue 1, Pages (January 2019) DOI: /j.jid Copyright © 2018 The Authors Terms and Conditions

2 Figure 1 Regulation of KRT9 expression in volar keratinocytes. (a) KRT9 is a specific marker of suprabasal epithelial cells in volar skin. (b) KRT9 expression is decreasing in volar keratinocytes over time with passages, concomitant with the induction of DDX58, STAT1, and KRT7. (c) Treatment of poly(I:C) reduces KRT9 expression; in contrast, KRT9 is induced by DDX58 or STAT1 siRNA. dsRNA, double-stranded RNA; KRT, keratin; P, passage; poly(I:C), polyinosinic:polycytidylic acid. Journal of Investigative Dermatology  , 17-19DOI: ( /j.jid ) Copyright © 2018 The Authors Terms and Conditions


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