1. Dietary administration of DHEA reduces jet‐lag
Dietary administration of DHEA reduces jet‐lag Effect of chronic DHEA administration (1.0% w/w; vertical line) on wheel‐running activity in mice during re‐entrainment to a 6‐h phase‐advanced LD cycle. Representative double‐plotted actograms of control (n = 12; left) and DHEA‐treated (n = 11; middle) animals. Activity onset (mean ± SEM) during a 6‐h phase advance was plotted (right panel) and analyzed by a Welch's t‐test (**P < 0.01). All statistical information is shown in Appendix Table S1.Effect of acute DHEA (3 days of 1.0% w/w) on wheel‐running activity in mice during a 6‐h phase‐advanced LD cycle. Representative double‐plotted actograms of control (n = 10; left) and DHEA‐treated (n = 11; middle) animals. Activity onset during a 6‐h phase‐advanced LD cycle (mean ± SEM) (right panel). Data were analyzed by a Welch's t‐test (*P < 0.05, **P < 0.01). All statistical information is shown in Appendix Table S1.Effect of acute DHEA (3 days of 1.0% w/w; red bar above) on body temperature rhythms. After surgical implantation of temperature devices, body temperature was measured for the duration of the experiment. Data are shown for 2.5 days of entrainment to a LD cycle and then 7.5 days of exposure to a 6‐h phase advance LD cycle. Data represent the mean of each treatment.Effect of acute DHEA (3 days of 1.0% w/w) and exposure to a 6‐h phase‐advanced LD cycle (3 days) and then return to normal food and transfer into DD. Representative double‐plotted actograms of control (n = 10; left) and DHEA‐treated (n = 11; middle) animals. Activity onset was plotted during a 6‐h phase‐advanced LD cycle and then transfer into DD (mean ± SEM) (right panel). Data were analyzed by a Welch's t‐test (*P < 0.05, **P < 0.01). All statistical information is shown in Appendix Table S1.
T Katherine Tamai et al. EMBO Mol Med. 2018;emmm
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