1. Pharmacokinetic Modeling and Simulation of Procainamide and N-Acetylprocainamide in a Patient Receiving Continuous Renal Replacement Therapy: A Novel Approach to Guide Renal Dose Adjustments 
Ahmed N. Mohamed, PhD, Ahmed M. Abdelhady, MS, Dustin Spencer, PharmD, Kevin M. Sowinski, PharmD, James E. Tisdale, PharmD, Brian R. Overholser, PharmD 
American Journal of Kidney Diseases 
Volume 61, Issue 6, Pages (June 2013)
DOI: /j.ajkd
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2. Figure 1
Simulated plasma concentration-time profiles after 3 different dosing regimens with 30-minute loading and 48-hour maintenance doses. (A) Loading dose: 20 mg/min; maintenance dose: 4 mg/min. (B) Loading dose: 20 mg/min; maintenance dose: 2 mg/min. (C) Loading dose: 20 mg/min; maintenance dose: 1 mg/min. The horizontal solid and dashed lines represent therapeutic ranges for procainamide and combined procainamide/NAPA concentrations, respectively.
American Journal of Kidney Diseases  , DOI: ( /j.ajkd )
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