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Fig. 4. Expression of HGF in liver ECs cooperates with NOX4 inhibition to enhance engraftment of regenerative hepatocytes. Expression of HGF in liver ECs.

Published byEmma Filippi Modified over 5 years ago

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Presentation on theme: "Fig. 4. Expression of HGF in liver ECs cooperates with NOX4 inhibition to enhance engraftment of regenerative hepatocytes. Expression of HGF in liver ECs."— Presentation transcript:

1 Fig. 4. Expression of HGF in liver ECs cooperates with NOX4 inhibition to enhance engraftment of regenerative hepatocytes. Expression of HGF in liver ECs cooperates with NOX4 inhibition to enhance engraftment of regenerative hepatocytes. (A and B) Immunostaining (A) and Western blot (B) of NOX4 protein in the injured liver after injection of pseudotyped virus. Antibody Mec13.3 recognizing CD31 was conjugated with virus expressing Hgf (Mec13-Hgf) or scrambled sequence (Mec13-Srb). Virus was injected into the portal circulation. n = 8 mice in Mec13-Hgf group and 10 mice in Mec13-Srb group. (C to E) Liver hydroxyproline and MDA amounts in injured mice treated with Mec13-Hgf, NOX4 inhibitor GKT, or coinjection of Mec13-Hgf and GKT (Mec13-Hgf + GKT). n = 8, 10, 10, and 9 animals in individual groups from left to right in (C) and (D). Statistical analysis was performed with one-way ANOVA followed by Tukey’s post hoc test. (F) Incorporation of transplanted TdTomato+ hepatocytes in the liver tissue of mice 21 days after BDL. (G to I) Serum concentrations of aspartate aminotransferase (AST) (G), alanine aminotransferase (ALT) (H), and bilirubin (I) in indicated mouse groups after BDL. n = 12, 16, 14, 16, 15, and 12 animals in individual groups from left to right in (G) to (I). Statistical difference was determined by one-way ANOVA followed by Tukey’s post hoc test. Scale bars, 50 μm. Zhongwei Cao et al., Sci Transl Med 2017;9:eaai8710 Published by AAAS

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