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Should Methotrexate plus Calcineurin Inhibitors Be Considered Standard of Care for Prophylaxis of acute Graft-versus-Host Disease?  Rainer Storb, Joseph.

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Presentation on theme: "Should Methotrexate plus Calcineurin Inhibitors Be Considered Standard of Care for Prophylaxis of acute Graft-versus-Host Disease?  Rainer Storb, Joseph."— Presentation transcript:

1 Should Methotrexate plus Calcineurin Inhibitors Be Considered Standard of Care for Prophylaxis of acute Graft-versus-Host Disease?  Rainer Storb, Joseph H. Antin, Corey Cutler  Biology of Blood and Marrow Transplantation  Volume 16, Issue 1, Pages S18-S27 (January 2010) DOI: /j.bbmt Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Survival and cGVHD in patients with aplastic anemia (2-63 years old) given HLA matched-related grafts and receiving MTX/CsA after conditioning with cyclophosphamide and antithymocyte globulin (Cy/ATG) [87]. Similar results have been reported in children by Locatelli et al. [88]. Biology of Blood and Marrow Transplantation  , S18-S27DOI: ( /j.bbmt ) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Survival of patients with chronic myelogenous leukemia in chronic phase (CML-CP) given HLA-matched unrelated HCT and receiving MTX/CsA after conditioning with cyclophosphamide and total body irradiation (Cy/TBI) [89]. This represents a subgroup of patients who received prophylaxis with fluconazole and ganciclovir. Biology of Blood and Marrow Transplantation  , S18-S27DOI: ( /j.bbmt ) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions


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