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The Genetic Landscape of Malignant Pleural Mesothelioma: Results from Massively Parallel Sequencing  Marieke Hylebos, MSc, Guy Van Camp, PhD, Jan P van.

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Presentation on theme: "The Genetic Landscape of Malignant Pleural Mesothelioma: Results from Massively Parallel Sequencing  Marieke Hylebos, MSc, Guy Van Camp, PhD, Jan P van."— Presentation transcript:

1 The Genetic Landscape of Malignant Pleural Mesothelioma: Results from Massively Parallel Sequencing 
Marieke Hylebos, MSc, Guy Van Camp, PhD, Jan P van Meerbeeck, MD, PhD, Ken Op de Beeck, PhD  Journal of Thoracic Oncology  Volume 11, Issue 10, Pages (October 2016) DOI: /j.jtho Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Overview of the following studies using massively parallel sequencing in malignant pleural mesothelioma. Data from Bueno et al.,27 Guo et al.,28 Mäki-Nevala et al.,30 Kang et al.,31 Sugarbaker et al.,25 Dong et al.,26 and Lo Iacono et al.29 Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 CONSORT diagram of the electronic search strategy.
Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 Affected pathways in malignant pleural mesothelioma. Observed mutations cluster in four main pathways: the tumor protein p53 (TP53)/DNA-repair pathway (orange), the cell cycle pathway (blue), the mitogen-activated protein kinase (MAPK) pathway (green), and the phophatidylinositol-3 kinase (PI3K)-AKT pathway (purple). ATM, ATM serine/threonine kinase; BAP1, BRCA1 associated protein 1; MDM2, MDM2 proto-oncogene, E3 ubiquitin protein ligase; CUL1, cullin 1; CDK2, cyclin-dependent kinase 2; PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; PIK3C2B, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type beta; PTEN, phosphatase and tensin homolog; TAOK1, TAO kinase 1; mTOR, mammalian target of rapamycin; MAP2K6, mitogen-activated protein kinase kinase 6; KDR, kinase insert domain receptor; KIT, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog. Data from the following sources, cited in the figure as numbers , Bueno et al.27; 2, Guo et al.28; 3, Mäki-Nevala et al.30; 4, Kang et al.31; 5, Dong et al.26; and 6, Lo Iacono et al.29 Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

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