1. Comparison of the sedative properties of CNS 7056, midazolam, and propofol in sheep 
R.N. Upton, A.M. Martinez, C. Grant 
British Journal of Anaesthesia 
Volume 103, Issue 6, Pages (December 2009)
DOI: /bja/aep269
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

2. Fig 1
The effect of CNS 7056 on EEG α power. A loess smoothing function was applied to the pooled EEG data for each dose group. The drug infusions were from 0 to 2 min. Note that the smoothing function is responsible for the slight increase in α power before the start of drug administration at time zero.
British Journal of Anaesthesia  , DOI: ( /bja/aep269)
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

3. Fig 2
The effect of midazolam on EEG α power. A loess smoothing function was applied to the pooled EEG data for each dose group. The drug infusions were from 0 to 2 min.
British Journal of Anaesthesia  , DOI: ( /bja/aep269)
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

4. Fig 3
The effect of propofol on EEG α power. A loess smoothing function was applied to the pooled EEG data for each dose group. The drug infusions were from 0 to 2 min.
British Journal of Anaesthesia  , DOI: ( /bja/aep269)
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

5. Fig 4
Change in arterial oxygen tension vs depth of anaesthesia. This graph shows the relationship between the maximum change in the α power of the EEG (reflecting the depth of anaesthesia) and the change in arterial oxygen tension (Pao2) at 2 min, reflecting the magnitude of respiratory depression. Each symbol is the mean of one dose group for the drugs shown. The R2 value of the line of best fit was 0.78, the slope was [mean (se)] −2.37 (0.45) (P<0.01). The non-zero slope of the line supports the general hypothesis that (regardless of the drug) the greater the anaesthesia, the greater the respiratory depression.
British Journal of Anaesthesia  , DOI: ( /bja/aep269)
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

6. Fig 5
Change in MAP vs depth of anaesthesia. This graph shows the relationship between the maximum change in the α power of the EEG (reflecting the depth of anaesthesia) and the change in MAP at 2 min, reflecting the magnitude of cardiovascular depression. Each symbol is the mean of one dose group for the drugs shown. The R2 value of the line of best fit was 0.39, the slope was [mean (se)] −0.61 (0.27) (P=0.05). Although not statistically significant, trend in the data supports the general hypothesis that (regardless of the drug) the greater the anaesthesia, the greater the cardiovascular depression.
British Journal of Anaesthesia  , DOI: ( /bja/aep269)
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

7. Fig 6
Change in heart rate vs depth of anaesthesia. This graph shows the relationship between the maximum change in the α power of the EEG (reflecting the depth of anaesthesia) and the maximum change in heart rate, reflecting the magnitude of cardiovascular depression. Each symbol is the mean of one dose group for the drugs shown. The R2 value of the line of best fit was 0.75, the slope was [mean (se)] 3.37 (0.68) (P<0.01). The non-zero slope of the line supports the general hypothesis that (regardless of the drug) the greater the anaesthesia, the greater the cardiovascular depression.
British Journal of Anaesthesia  , DOI: ( /bja/aep269)
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions