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Ubiquilin 2: Shuttling Clients Out of Phase?

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1 Ubiquilin 2: Shuttling Clients Out of Phase?
Ipsita Subudhi, James Shorter  Molecular Cell  Volume 69, Issue 6, Pages (March 2018) DOI: /j.molcel Copyright © 2018 Elsevier Inc. Terms and Conditions

2 Figure 1 UBQLN2 May Extract Ubiquitylated Clients from SGs
(A) Domain architecture of UBQLN1, UBQLN2, FUS, and TDP-43. The position of various domains including the PrLD is indicated. (B) In vivo, UBQLN2 LLPS enables UBQLN2 accumulation in SGs. Interactions between the PrLD of UBQLN2 and PrLDs of SG-resident RBPs may help fluidize the SG. Interactions between the UBA domain of UBQLN2 and ubiquitylated clients reverse UBQLN2 LLPS, which may enable UBQLN2 to shuttle clients out of SGs for proteasomal degradation. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2018 Elsevier Inc. Terms and Conditions

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