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Testing a Mechanism: Kinetic Isotope Effects

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Presentation on theme: "Testing a Mechanism: Kinetic Isotope Effects"— Presentation transcript:

1 Testing a Mechanism: Kinetic Isotope Effects
Primary Isotope Effect - rate change due to isotopic substitution at a site of bond breaking or bond making in the rate determining step of a mechanism. Secondary Isotope Effect - rate change due to isotopic substitution at other than a site of bond breaking or bond making in the rate determining step of a mechanism.

2 Primary Kinetic Isotope Effect: Typical Values

3 Examples of Kinetic Isotope Effects

4 More Examples of Kinetic Isotope Effects

5 Secondary Kinetic Isotope Effects
Differences in steric demand Hyperconjugative effects Differences in inductive effect

6 Examples of Secondary Kinetic Isotope Effects
Differences in Steric demand

7 Secondary Kinetic Isotope Effects

8 Secondary Kinetic Isotope Effects
Hyperconjugative effects

9 Secondary Kinetic Isotope Effects
Inductive effects

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