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Safety, pharmacokinetics, and immunogenicity of a co-formulated cocktail of three human monoclonal antibodies targeting Ebola virus glycoprotein in healthy adults: a randomised, first-in-human phase 1 study Sumathi Sivapalasingam, MD, Mohamed Kamal, PhD, Rabih Slim, PhD, Romana Hosain, MD, Weiping Shao, PhD, Randall Stoltz, MD, Joseph Yen, PhD, Laura G Pologe, PhD, Yuan Cao, PhD, Michael Partridge, PhD, Giane Sumner, PhD, Leah Lipsich, PhD The Lancet Infectious Diseases Volume 18, Issue 8, Pages (August 2018) DOI: /S (18) Copyright © 2018 Elsevier Ltd Terms and Conditions
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Figure 1 Trial profile Cohort 1: REGN mg/kg IV or placebo IV infused over 2 h. Cohort 2: REGN mg/kg IV or placebo IV infused over 2 h. Cohort 3: REGN mg/kg IV or placebo IV infused over 4 h. Cohort 4: REGN mg/kg IV or placebo IV infused over 4 h. IV=intravenous. The Lancet Infectious Diseases , DOI: ( /S (18) ) Copyright © 2018 Elsevier Ltd Terms and Conditions
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Figure 2 Mean log-scaled concentrations of total REGN3470, total REGN3471, and total REGN3479 in serum from healthy adults, by nominal time and treatment group Error bars show the SD of each mean. LLOQ=lower limit of quantification. The Lancet Infectious Diseases , DOI: ( /S (18) ) Copyright © 2018 Elsevier Ltd Terms and Conditions
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