1. Improving the safety of T-Cell therapies using an inducible caspase-9 gene 
Xiaoou Zhou, Malcolm K. Brenner 
Experimental Hematology 
Volume 44, Issue 11, Pages (November 2016)
DOI: /j.exphem
Copyright © 2016 ISEH - International Society for Experimental Hematology Terms and Conditions

2. Figure 1
Structure of the iC9 suicide gene. (A) The transgene consists of an inducible caspase-9 (iC9) and a selectable marker, truncated CD19 (ΔCD19), linked by a 2A-like sequence, which encodes a cleavable peptide. iC9 consists of a drug-binding domain (FKBP12-F36V) connected via a short linker (SGGGS) to human caspase-9. (B) Conditional caspase 9 dimerization is induced in the presence of CID (AP1903), cleaving caspase-3 and leading to cell apoptosis.
Experimental Hematology  , DOI: ( /j.exphem )
Copyright © 2016 ISEH - International Society for Experimental Hematology Terms and Conditions