1. Fungal Secretion: The Next-Gen Target of Antifungal Agents?
Julianne Teresa Djordjevic, Sophie Lev 
Cell Chemical Biology 
Volume 25, Issue 3, Pages (March 2018)
DOI: /j.chembiol
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2. Figure 1
Sec14p Controls an Interface between Lipid Metabolism and Vesicular Traffic through the trans-Golgi Network/Endosomal System
The current model of Sec14p function predicts that association of Sec14p with PC primes Sec14p for a heterotypic exchange reaction (PC→PI). This exchange is instrumental in presenting the PI head group in a conformation amenable to phosphorylation by the PI kinase, Pik1. The product of Pik1, PI4P, is a key phospholipid essential for maintaining the integrity of the Golgi apparatus, protein glycosylation, and formation of transport vesicles. Sec14p cannot stimulate Pik1 unless sufficient PC is available for heterotypic exchange. Thus, Sec14p functions as a PC sensor, transmitting PC metabolic information to PI4P biosynthesis. As PC levels increase due to synthesis via the CDP-choline pathway, Sec14p is activated for heterotypic exchange (PC→PI), stimulating PI phosphorylation by Pik1. Additionally, through its association with Sec14p, PC limits its own production: PC-bound Sec14p inhibits the rate-limiting step in PC biosynthesis (phosphocholine→CDP-choline), preventing overconsumption of diacylglycerol, which is essential for vesicular budding and other processes.
Cell Chemical Biology  , DOI: ( /j.chembiol )
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