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De novo autoimmune hepatitis after liver transplantation

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Presentation on theme: "De novo autoimmune hepatitis after liver transplantation"— Presentation transcript:

1 De novo autoimmune hepatitis after liver transplantation
Giorgina Mieli-Vergani, Diego Vergani  Journal of Hepatology  Volume 40, Issue 1, Pages 3-7 (January 2004) DOI: /j.jhep

2 Fig. 1 De novo autoimmune hepatitis post liver transplant. (A) Chronic hepatitis with moderate portal and interface mononuclear cell infiltrate, including plasma cells (haematoxilyn-eosin staining); (B) reticulin staining showing bridging collapse, a lesion resulting from extensive death of hepatocytes and consequent coalescence of the supportive structure (histological pictures kindly provided by Professor Bernard Portmann). Journal of Hepatology  , 3-7DOI: ( /j.jhep )

3 Fig. 2 (A) Heart transplant from an allogeneic mouse results not only in rejection, but also in the production of antibodies and CD4 T cells directed against cardiac myosin in the recipient. (B) Transplant of allogeneic skin or of a syngeneic heart do not lead to cardiac-specific autoimmunity, indicating that this response is tissue-specific and that an allogeneic response is necessary to break tolerance to cardiac myosin. Journal of Hepatology  , 3-7DOI: ( /j.jhep )


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