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Pooled analysis of two large randomised phase III inhaled mannitol studies in cystic fibrosis  Diana Bilton, Gabriel Bellon, Brett Charlton, Peter Cooper,

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Presentation on theme: "Pooled analysis of two large randomised phase III inhaled mannitol studies in cystic fibrosis  Diana Bilton, Gabriel Bellon, Brett Charlton, Peter Cooper,"— Presentation transcript:

1 Pooled analysis of two large randomised phase III inhaled mannitol studies in cystic fibrosis 
Diana Bilton, Gabriel Bellon, Brett Charlton, Peter Cooper, Kris De Boeck, Patrick A. Flume, Howard G. Fox, Charles G. Gallagher, David E. Geller, Eric G. Haarman, Helge U. Hebestreit, John Kolbe, Allen Lapey, Phil Robinson, Jian Wu, Jonathan B. Zuckerman, Moira L. Aitken  Journal of Cystic Fibrosis  Volume 12, Issue 4, Pages (July 2013) DOI: /j.jcf Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

2 Fig. 1 Flow-chart of the study.
Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

3 Fig. 2 Mean absolute (mL) change from baseline in FEV1 — ITT population. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

4 Fig. 3 % Change from baseline in % FEV1 predicted by age — ITT population. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

5 Fig. 4 a. Forest plot of FEV1 % change of % predicted. b. Forest plot of FVC % change of % predicted. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

6 Fig. 5 a. Relative risk for protocol defined pulmonary exacerbation by subgroups — ITT population. b. Time to first protocol defined pulmonary exacerbation — ITT population. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions


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