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Figure 1. Distribution of ABCB1 SNVs and haplotypes.

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Presentation on theme: "Figure 1. Distribution of ABCB1 SNVs and haplotypes."— Presentation transcript:

1 Figure 1. Distribution of ABCB1 SNVs and haplotypes.
Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( J Antimicrob Chemother, Volume 74, Issue 4, 09 January 2019, Pages 1012–1020, The content of this slide may be subject to copyright: please see the slide notes for details.

2 Figure 2. Observed daptomycin concentrations versus model predictions
Figure 2. Observed daptomycin concentrations versus model predictions. The black line is the line of identity (y = x) ... Figure 2. Observed daptomycin concentrations versus model predictions. The black line is the line of identity (y = x) and the magenta line is a spline regression. This figure appears in colour in the online version of JAC and in black and white in the print version of JAC. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( J Antimicrob Chemother, Volume 74, Issue 4, 09 January 2019, Pages 1012–1020, The content of this slide may be subject to copyright: please see the slide notes for details.

3 Figure 3. Scatterplot and distribution of NPDE
Figure 3. Scatterplot and distribution of NPDE. Upper panel, NPDE versus model predictions; lower panel, probability ... Figure 3. Scatterplot and distribution of NPDE. Upper panel, NPDE versus model predictions; lower panel, probability density function (pdf) of empirical (magenta line) and theoretical (black dashed line) NPDE. This figure appears in colour in the online version of JAC and in black and white in the print version of JAC. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( J Antimicrob Chemother, Volume 74, Issue 4, 09 January 2019, Pages 1012–1020, The content of this slide may be subject to copyright: please see the slide notes for details.

4 Figure 4. Prediction-corrected visual predictive check from the final model. The black dots are the observations. The ... Figure 4. Prediction-corrected visual predictive check from the final model. The black dots are the observations. The blue solid lines are the 10<sup>th</sup> and 90<sup>th</sup> percentiles of prediction-corrected daptomycin concentrations and the magenta solid line is the median of observations (i.e. 50th percentile). The blue areas are the 90% CIs of the 10th and 90th simulated percentiles and the pink area is the 90% CI of the simulated median. Simulated percentiles were obtained from 1000 replicates of each individual dataset and the final model parameter estimates. Observations greater than 100 mg/L (n = 9) are not shown for ease of graphical display. Of note, the x-axis represents the time after the previous dose, i.e. the dose administered the day before TDM was performed. This figure appears in colour in the online version of JAC and in black and white in the print version of JAC. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( J Antimicrob Chemother, Volume 74, Issue 4, 09 January 2019, Pages 1012–1020, The content of this slide may be subject to copyright: please see the slide notes for details.

5 Figure 5. Probability of achieving target values of fAUC24/MIC and fCmax/MIC ratio for various ...
Figure 5. Probability of achieving target values of fAUC<sub>24</sub>/MIC and fC<sub>max</sub>/MIC ratio for various daptomycin dosages and covariate status. Top, 6 mg/kg/24 h; middle, 8 mg/kg/24 h; bottom, 10 mg/kg/24 h. In the figure legend, ‘AUC’ means fAUC<sub>24</sub>/MIC target, while ‘C<sub>max</sub>’ means fC<sub>max</sub>/MIC target. ‘CGC’ means homozygous CGC/CGC haplotype, while ‘no CGC’ means any other genotype. This figure appears in colour in the online version of JAC and in black and white in the printed version of JAC. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( J Antimicrob Chemother, Volume 74, Issue 4, 09 January 2019, Pages 1012–1020, The content of this slide may be subject to copyright: please see the slide notes for details.

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