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Heparin-induced thrombosis without thrombocytopenia

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1 Heparin-induced thrombosis without thrombocytopenia
Frederick A. Tibayan, MD, Lawrence L. Leung, MD, Thomas A. Burdon, MD, James I. Fann, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 139, Issue 2, Pages e6-e7 (February 2010) DOI: /j.jtcvs Copyright © Terms and Conditions

2 Figure 1 Clinical course and platelet count of patient with HIT (dashed line and triangles). A, Admission. B, Immediately after 2-vessel off-pump CABG, 213 K/μL; C, Platelet nadir, 168 K/μL (heparin-induced antibody negative at this time). D, CT of chest with saddle pulmonary embolus (heparin-induced antibody and heparin-induced platelet aggregation positive). Mean platelet count ± standard error of the mean of 21 consecutive patients who underwent off-pump coronary artery bypass during same time period as patient with HIT (solid line and squares). HITT, Heparin-induced thrombocytopenia and thrombosis. The Journal of Thoracic and Cardiovascular Surgery  , e6-e7DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

3 Figure 2 Computed tomography of the chest obtained on postoperative day 12 demonstrating a large saddle pulmonary embolus. Tests for heparin-induced antibody and heparin-induced platelet aggregation were both positive at this time, although the patient was not thrombocytopenic and never had a significant decrease in platelet count. The Journal of Thoracic and Cardiovascular Surgery  , e6-e7DOI: ( /j.jtcvs ) Copyright © Terms and Conditions


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