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Gut Microbiota and Its Possible Relationship With Obesity

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Presentation on theme: "Gut Microbiota and Its Possible Relationship With Obesity"— Presentation transcript:

1 Gut Microbiota and Its Possible Relationship With Obesity
John K. DiBaise, MD, Husen Zhang, PhD, Michael D. Crowell, PhD, Rosa Krajmalnik-Brown, PhD, G. Anton Decker, MBBCh, MRCP, Bruce E. Rittmann, PhD  Mayo Clinic Proceedings  Volume 83, Issue 4, Pages (April 2008) DOI: / Copyright © 2008 Mayo Foundation for Medical Education and Research Terms and Conditions

2 FIGURE 1 Steps for building a clone library to fingerprint a complex microbial community. PCR = polymerase chain reaction; rRNA = ribosomal RNA. Mayo Clinic Proceedings  , DOI: ( / ) Copyright © 2008 Mayo Foundation for Medical Education and Research Terms and Conditions

3 FIGURE 2 Key physiologic and microbiological features of the gut. Relative concentrations of bacteria and the pH at various locations within the adult gut are also noted. cfu = colony-forming unit. Mayo Clinic Proceedings  , DOI: ( / ) Copyright © 2008 Mayo Foundation for Medical Education and Research Terms and Conditions

4 FIGURE 3 Mechanisms by which the intestinal microbiota may contribute to obesity. AMPK = adenosine monophosphate-activated protein kinase; ChREBP = carbohydrate response element-binding protein; Fiaf = fasting-induced adipocyte factor; LPL = lipoprotein lipase; LPS = lipopolysaccharide; PGC-1α = peroxisome proliferator-activated receptor γ coactivator 1α; SREBP-1 = sterol response element-binding protein type 1. Mayo Clinic Proceedings  , DOI: ( / ) Copyright © 2008 Mayo Foundation for Medical Education and Research Terms and Conditions


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