1. Crash Course on Extending the Human Lifespan

2. What can shorten a human lifespan?

3. Cardiovascular Disease Communicable Diseases Diseases of old age – Cell atrophy: arthritis, Huntington's, Multiple Sclerosis – Mental: Alzheimer's, dementia, etc. Cancer

4. Deaths in 2004 according to the WHO TOTAL Deaths 58 772100.0 Cause# of deaths % of total deaths Cardiovascular diseases 17 07329.0 Respiratory diseases 4 0366.9 Diabetes mellitus 1 1411.9 Infectious and parasitic diseases 9 51916.2 Respiratory infections 4 2597.2 Neuropsychiatric disorders 1 2632.1 Alzheimer and other dementias 4920.8 Parkinson disease 1100.2 Malignant neoplasms 7 42412.6 Solutio n Reversatrol Rapamycin SENS Proposal All Three

5. Shortened lifespan due to lifestyle TOTAL Deaths 58 772100.0 Cause# of deaths % of total deaths Cardiovascular diseases 17 07329.0 Respiratory diseases 4 0366.9 Diabetes mellitus 1 1411.9 Solutio n Reversatrol Cardiovascular and Respiratory diseases, and Type 2 Diabetes were responsible for 37.8% of deaths in 2004. These problems arise from lifestyle choices; obesity, unhealthy diet, smoking, uncontrolled blood pressure and blood sugar, etc.

6. Solution to Lifestyle: Reversatrol Calorie restricted diet American diet WITH Reversatrol American diet WITHOUT Reversatrol Normal BP Healthy Metabolism Good endurance Normal BP Healthy Metabolism Good endurance High BP Unhealthy Metabolism No endurance

7. Solution to Lifestyle: Reversatrol Reduced heart disease, diabetes, lower BP Will most likely die from heart disease, diabetes, or high BP Reduced heart disease, diabetes, lower BP Calorie restricted diet American diet WITH Reversatrol American diet WITHOUT Reversatrol

8. Shortened lifespan due to Infections TOTAL Deaths 58 772100.0 Cause# of deaths % of total deaths Infectious and parasitic diseases 9 51916.2 Respiratory infections 4 2597.2 Solutio n SENS Proposal Infectious diseases and respiratory infections were responsible for 23.4% of deaths in 2004. These infections arose from two main sources; Unavailability of vaccines (poor countries) and the bodies regular immune system being just not good enough

9. Solution to Infections: SENS Proposal Transpantation and Tissue Engineering – Infections of organs Cell Therapy – Eliminates infections of (and non-performance) cells Germline Therapy – Altering a zygote so that an organism can grow from birth with DNA that is unable to mutate Sens & sens research; delivery. (2010). Retrieved from http://www.sens.org/sens-research/research-themes/delivery

10. Shortened lifespan due to Old Age Solutio n Degenerative and psychiatric diseases were responsible for more than 3.1% of deaths in 2004. These problems arise from genetics and cell atrophy (cell death) TOTAL Deaths 58 772100.0 Cause# of deaths % of total deaths Neuropsychiatric disorders 1 2632.1 Alzheimer and other dementias 4920.8 Parkinson disease 1100.2 Rapamycin

11. Solution to Cell Atrophy: Rapamycin Immunosuppressive therapy to help prevent organ rejection in transplant patients. Only showed life extending qualities when introduced in old age. Why?

12. Solution to Cell Atrophy: Rapamycin Immunosuppressive therapy to help prevent organ rejection in transplant patients. Only showed life extending qualities when introduced in old age Rapamycin has an effect on the telomere – Slows cell atrophy by extending the telomeres of DNA

13. Shortened lifespan due to Cancer Solutio n Cancer was responsible for than 12.6% of deaths in 2004. Cancer arises from…? A combination of obesity, unhealthy diet, smoking, uncontrolled blood pressure and blood sugar, bodies regular immune system being just not good enough, genetics and cell atrophy (cell death) Use of all three proposals TOTAL Deaths 58 772100.0 Cause# of deaths % of total deaths Malignant neoplasms 7 42412.6

14. Solution to Cancer: combination of all 3 new technologies Using Reversatrol, the SENS Proposal, and Rapamycin, we can greatly reduce our exposure and risk to mutations of our cells (cancer)

15. Reversatrol on Cancer Obesity, high blood pressure, high blood sugar, and the physiological effects of an unhealthy lifestyle can be eliminated, which reduces chances of mutated cells Obviously, this does not apply to smoking or eating asbestos.

16. The SENS Proposal on Cancer Transpantation and Tissue Engineering for effected organs/tissue Germline Therapy applied so that the DNA cannot mutate

17. Rapamycin on Cancer Cancer takes advantage of the Telomere of cells and can actually keep the cells alive to reproduce the mutated DNA Applying Rapamycin backwards, we could treat cancerous cells by targeting their telomere supplies