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Interstitial tumor-associated macrophages combined with tumor-derived colony- stimulating factor-1 and interleukin-6, a novel prognostic biomarker in non–small.

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Presentation on theme: "Interstitial tumor-associated macrophages combined with tumor-derived colony- stimulating factor-1 and interleukin-6, a novel prognostic biomarker in non–small."— Presentation transcript:

1 Interstitial tumor-associated macrophages combined with tumor-derived colony- stimulating factor-1 and interleukin-6, a novel prognostic biomarker in non–small cell lung cancer  Bao-xiang Pei, MD, Bing-sheng Sun, MD, PhD, Zhen-fa Zhang, MD, PhD, An-lei Wang, MD, Peng Ren, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 148, Issue 4, Pages e2 (October 2014) DOI: /j.jtcvs Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Typical expression images of macrophage colony-stimulating factor (CSF-1), interleukin-6 (IL-6), and CD68 immunohistochemistry in tissue microarrays. Original magnification: CSF-1–positive (CSF1+): A, ×40; and B, ×200; CSF-1–negative (CSF1−): C, ×40; and D, ×200; IL-6–positive (IL6+): E, ×40; and F, ×200; IL-6–negative (IL6−): G, ×40; H, ×200; CD68-positive (CD68+): I, ×40 and J, ×200; CD68-negative (CD68−): K, ×40; and L, ×200×. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Prognostic significance assessed using Kaplan-Meier survival estimates and log-rank tests. Kaplan-Meier analysis of (A) overall survival (OS) and (B) disease-free survival (DFS) for CD68. Comparisons of OS and DFS by (C) CD68-positive (CD68+), colony-stimulating factor-1 (CSF-1)–positive (CSF1+), interleukin (IL)-6–negative (IL6−) and (D) CD68+, CSF-1–negative (CSF1−), IL-6–negative (IL6−); (E) CD68+, CSF1−, IL6+ and F, CD68+, CSF1−, IL6−. Cum, Cumulative. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Kaplan-Meier analysis of (A) overall survival (OS) and (B) disease-free survival (DFS) for the combination of CD68, colony-stimulating factor-1 (CSF-1), and interleukin-6 (IL-6). Comparisons of OS and DFS by (C) CD68-negative (CD68−), CSF-1–positive (CSF1+), IL-6–positive (IL6+) and (D) CD68-positive (CD68+), CSF1+, IL6+. Cum, Cumulative. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

5 Figure E1 A and B, Overall survival (OS) and disease-free survival (DFS) for combined colony-stimulating factor (CSF-1) and interleukin-6 (IL-6) and tumor-associated macrophages (TAMs) in patients with adenocarcinoma. C and D, OS and DFS for combined CSF-1 and IL-6 and TAMs in patients with non–small cell lung cancer at stage I. E and F, OS and DFS for combined CSF-1 and IL-6 and TAMs in patients with stage I adenocarcinoma. Cum, Cumulative; +, positive; −, negative. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

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